Investigación sobre microdosificación

This is the fourth publication on the administration of a microdose of LSD (5, 10, or 20µg). The double-blind, placebo-controlled study (n=24) found enhanced attention, slower information processing, more positive mood, and increased anxiety and confusion. Again, the results are small and ambiguous.

A placebo-controlled within-subject study including, 24 healthy participants, was conducted to assess the acute effects of three LSD doses (5, 10, and 20 mcg) on measures of cognition, mood, and subjective experience.

This qualitative study (n=198) of opinions on microdosing found that they were generally well-tolerated and were used for therapeutic or enhancement purposes. The study analysed 32 videos and the self-report reactions to those videos.

This survey study (n=525) found that the motivation for microdosing (psilocybin and LSD) was mainly to improve mental health, personal development, and cognitive enhancement. Four out of five participants used one or more harm reduction techniques on microdosing days (e.g. not dosing when unwell, no alcohol, avoiding driving).

This prospective survey study (n=81) found that expectancy effects were mostly predictive of microdosing outcomes on reductions in state anxiety, depressive symptoms (at 4-week endpoint), and positive outcomes (e.g. psychological resilience, -connectedness, -flexibility).

This review (2020) examines the viability of microdosing psychedelics as a method to improve cognition and well-being. Available evidence indicates a variety of (perceived) benefits, including improvements in mood, focus, and creativity, with some people experiencing no discernible effects or expressing concerns about selective negative consequences like increased anxiety. However, most insights stem from observational studies using convenience samples that are biased or unrepresentative of the general population.

This double-blind placebo-controlled study (n=30) found that microdosing psychedelics (psilocybin; 1.5mg; 5-7 doses) increased awe but not aesthetic experiences (e.g. viewing art). Many participants knew which group (receiving placebo or psilocybin in which timeframe) they were in (‘breaking blind’) and the researcher presume that expectancy-effects may explain the effects found.

This survey study (n=116) investigated the motives and reported side effects of psychedelic microdosing (.5g psilocybin (mushroom), 10μg LSD) and found that one-fifth (20%) of all microdosers reported some psychological or physical adverse effects. While most users pursued performance enhancement, many discontinued this practice primarily because it was ineffective.

This survey study (n=410) showed that those with mental & physical health problems self-rated the effectiveness of microdosing as higher than conventional treatments in regards to ADHD/ADD and anxiety. They rated it as less effective than a high dose of psychedelics.

This animal study (n=35) investigated the effects of microdosing DMT (1mg/kg) in rats and found that a chronic (∼2 months), intermittent (every third day) microdosing regimen facilitated fear extinction learning and reduced depressive immobility in the forced swim test without producing the anxiety-like effects characteristic of a high dose.