Investigación sobre microdosificación

This interview study (n=4 couples) explored the MDMA micro-dosing sexual experiences of four partnered men and women. Thematic analysis identified three key narratives: increased sexual self-efficacy; sexual exploration; and heightened relationship satisfaction. The use of microdosing MDMA had a positive effect on sexual and physical well-being by reducing stress and performance-related anxiety. Whilst higher doses of MDMA hindered sexual functioning this did not negatively impact the emotional and sensory experiences.

This preprint (n=41) explores how people use low doses of psychedelics to complement high-dose therapeutic and spiritual experiences by conducting a secondary analysis of interviews from a private-sector wellness company that provides psychedelics educational materials and coaching. High-dose psychedelics are most often meaningful for belief re-appraisal and acute mental illness, while lose-dose experiences benefit behavioural change, relationship development, and managing episodic stress. Low dosing appears to help users “integrate” the existential and therapeutic insights from high doses by improving in-the-moment mindfulness of everyday challenges.

These two randomised, double-blind, placebo-controlled trials (n=141) conducted in semi-naturalistic settings found that microdosing psilocybin truffles did not significantly affect cognitive control, memory, social cognition, subjective well-being, attention, mood, or self-reported cognitive flexibility compared to placebo. Initial effects in some domains did not remain significant after correcting for multiple comparisons.

This open-label Phase IIa trial (n=19, 15 male) found that an 8-week regimen of microdosed LSD (8μg initially, then 6-20μg twice weekly) for major depressive disorder was well-tolerated with no serious adverse events or cardiac valvulopathy, achieved 59.5% reduction in MADRS scores sustained for six months, and had only one withdrawal due to anxiety.

Analyzing brain activity through specific frequency bands reveals subtle shifts in brain organization that standard broad-spectrum analysis often misses.

Participants with major depressive disorder reported feeling more motivated, more connected to others, and better able to process emotions during an eight-week LSD microdosing trial.

Microdosing psilocybin can improve the quality of creative thinking by helping people come up with more original ideas.

Low doses of psilocybin may reduce the frequency of migraine attacks, but a two-dose “pulsed” schedule did not show a significant advantage over a single dose in this trial.

About 1 in 15 young adults in the United States reported microdosing hallucinogens in the past year.

Caregivers of people with advanced cancer often find that psychedelic-assisted therapy can strengthen their relationships and provide a sense of hope during difficult times.